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Contractile perinuclear actomyosin network promotes peripheral and polar chromosome interaction with the mitotic spindle

Chromosomes must efficiently and properly interact with the mitotic spindle during prometaphase for correct segregation in anaphase. Chromosomes at the nuclear periphery or behind the spindle poles interact less efficiently with the mitotic spindle, increasing the risk of missegregation. The mechani...

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Principais autores: Nooshin Sheidaei, John K Eykelenboom, Zuojun Yue, Graeme Ball, Alexander JR Booth, Tomoyuki U Tanaka
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2026-06-01
Serier:eLife
Fag:
perinuclear actomyosin network
PANEM
peripheral chromosomes
polar chromosomes
chromosome congression
kinetochore interaction with spindle microtubules
Online adgang:https://elifesciences.org/articles/110952
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