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Reduction of N-Acetylglucosaminyltransferase-I Activity Promotes Neuroblastoma Invasiveness and EGF-Stimulated Proliferation In Vitro

Aberrant N-glycosylation has been associated with progression of the pediatric cancer neuroblastoma (NB) but remains understudied. Here we investigated oligomannose N-glycans in NB by genetic editing of <i>MGAT1</i> in a human NB cell line, BE(2)-C, called BE(2)-C(MGAT1<sup>−/−</sup>). Lectin bindin...

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Ngā kaituhi matua: Adam P. Burch, M. Kristen Hall, Debra Wease, Ruth A. Schwalbe
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2024-08-01
Rangatū:International Journal of Translational Medicine
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Urunga tuihono:https://www.mdpi.com/2673-8937/4/3/35
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