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The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats

Status epilepticus (SE) is a severe clinical manifestation of epilepsy accompanying with cognitive impairment and brain damage. Astrocyte activation occurs following seizures and plays an important role in epilepsy-induced pathological injury, including cognitive impairment. FK506, an immunosuppress...

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Principais autores: Jinzhi Liu, Zhihua Si, Shuqing Li, Zhan Huang, Yan He, Tao Zhang, Aihua Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-01-01
Serier:Frontiers in Cellular Neuroscience
Fag:
epilepsy
cognitive impairment
astrogliosis
neuroprotection
FK506
Online adgang:http://journal.frontiersin.org/article/10.3389/fncel.2017.00428/full
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