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Preventive effects of crocin and meloxicam on morphine withdrawal symptoms in mice: behavioral and biochemical insights

Abstract Background The development of opioid-induced dependency is associated with several mechanisms, including oxidative stress, increase in inflammatory cytokines, and the activation of the glutamatergic system. This study investigates the effects of crocin, a bioactive compound from saffron, an...

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Principais autores: Tahereh Eteraf-Oskouei, Adel Mahmoudi Gharehbaba, Sarah Majidpour, Bohloul Habibi Asl
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-10-01
Series:BMC Pharmacology and Toxicology
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Acceso en liña:https://doi.org/10.1186/s40360-025-00999-9
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