Single-cell transcriptomics reveals notch regulation in quiescent LEPR⁺ endometrial mesenchymal stem cells

Abstract Background The human endometrium is a regenerative tissue relying on stem/progenitor cells. Endometrial mesenchymal stem cells (eMSCs) are typically enriched using perivascular markers like CD140b and CD146. However, the identity of more primitive and quiescent eMSC subpopulations remains u...

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Detalhes bibliográficos

Principais autores:	Yuan Fang, Dandan Cao, Cheuk-Lun Lee, Philip C. N. Chiu, Ernest H. Y. Ng, William S. B. Yeung, Rachel W. S. Chan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Endometrial stem cells Leptin receptor Single-cell RNA sequencing Stem cell quiescence Clonogenic Notch signaling
Acesso em linha:	https://doi.org/10.1186/s13287-025-04803-7
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