Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for nalfurafine, and recently. CR845 (difelikefalin). Ac...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Chongguang Chen, Peng Huang, Kathryn Bland, Mengchu Li, Yan Zhang, Lee-Yuan Liu-Chen
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2022-05-01
Цуврал:	Frontiers in Pharmacology
Нөхцлүүд:	kappa opioid receptor receptor phosphorylation receptor internalization conditioned place aversion sedation motor incoordination
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fphar.2022.835809/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!