Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly

Polynucleotide phosphorylase (PNPase) is an exoribonuclease that cleaves single-stranded RNA substrates with 3′–5′ directionality and processive behaviour. Its ring-like, trimeric architecture creates a central channel where phosphorolytic active sites reside. One face of the ring is decorated with...

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Detalles Bibliográficos

Principais autores:	Steven W. Hardwick, Tobias Gubbey, Isabelle Hug, Urs Jenal, Ben F. Luisi
Formato:	Artigo
Idioma:	Inglês
Publicado:	The Royal Society 2012-01-01
Series:	Open Biology
Assuntos:	polynucleotide phosphorylase rna degradosome caulobacter crescentus rna–protein interactions molecular ratchet conformational asymmetry
Acceso en liña:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.120028
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