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Validation of an RP-HPLC Method for the Determination of Asenapine Maleate in Dissolution Media and Application to Study In Vitro Release from Co-Crystals

Asenapine maleate is an antipsychotic drug that is indicated in the treatment of schizophrenia and bipolar disorders. It has low aqueous solubility and high permeability (Class II drug) and undergoes an extensive first pass effect. These problems result in low oral bioavailability (<2%). To enhance...

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Principais autores: Suhair S. Al-Nimry, Mai S. Khanfar
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2021-03-01
סדרה:Scientia Pharmaceutica
נושאים:
asenapine maleate
RP-HPLC method
validation
co-crystals
application
in vitro release
גישה מקוונת:https://www.mdpi.com/2218-0532/89/1/14
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