11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis.

Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. Ang...

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Hlavní autoři:	Callam T Davidson, Eileen Miller, Morwenna Muir, John C Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P Webster, Natalie Z M Homer, Ruth Andrew, Valerie G Brunton, Patrick W F Hadoke, Brian R Walker
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2023-01-01
Edice:	PLoS ONE
On-line přístup:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0255709&type=printable
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