Benzofuran-Annulated Naphthalimides Trigger Replication Stress, DNA Damage, and p53-Dependent Cell Cycle Arrest

<b>Background/Objectives:</b> DNA-targeting small molecules that induce replication stress represent a promising strategy in anticancer drug development. 1,8-Naphthalimide (NI) derivatives are well-established DNA-intercalating agents, and heterocyclic annulation offers a rational approach to enhanc...

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Autores principales:	Zlatina Vlahova, Lazar Lazarov, Maria Petrova, Shazie Yusein-Myashkova, Jordana Todorova, Maria Schröder, Monika Mutovska, Stanimir Stoyanov, Yulian Zagranyarski, Iva Ugrinova
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2026-06-01
Colección:	Pharmaceutics
Materias:	benzofuran naphthalimide anticancer agents replication stress DNA damage γH2AX
Acceso en línea:	https://www.mdpi.com/1999-4923/18/6/754
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