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Polypyrimidine tract-binding proteins are essential for B cell development

Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of bot...

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Principais autores: Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2020-02-01
coleção:eLife
Assuntos:
B cell development
RNA-binding proteins
alternative splicing
cell cycle
Acesso em linha:https://elifesciences.org/articles/53557
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