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Niche Laminin and IGF-1 Additively Coordinate the Maintenance of Oct-4 Through CD49f/IGF-1R-Hif-2α Feedforward Loop in Mouse Germline Stem Cells

The mechanism on how extracellular matrix (ECM) cooperates with niche growth factors and oxygen tension to regulate the self-renewal of embryonic germline stem cells (GSCs) still remains unclear. Lacking of an appropriate in vitro cell model dramatically hinders the progress. Herein, using a serum-f...

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Principais autores: Heng-Kien Au, Syue-Wei Peng, Chin-Lin Guo, Chien-Chia Lin, Yi-Lin Wang, Yung-Che Kuo, Tsz-Yau Law, Hong-Nerng Ho, Thai-Yen Ling, Yen-Hua Huang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-07-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
germline stem cell
niche
extracellular matrix
hypoxia
laminin
IGF
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2021.646644/full
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