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Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential

Osteogenesis imperfecta (OI) is a rare genetic disease characterized by bone fragility and bone formation. Sclerostin could negatively regulate bone formation by antagonizing the Wnt signal pathway, whereas it imposes severe cardiac ischemic events in clinic. Our team has screened an aptamer that co...

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Furkejuvvon:
Váldodahkkit: Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2024-03-01
Ráidu:Molecular Therapy: Nucleic Acids
Fáttát:
MT: Oligonucleotides: Therapies and Applications
quinoline modification
sclerostin aptamer
binding affinity
bone anabolic potential
modified aptamer library
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2162253124000337
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