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Soluble guanylyl cyclase beta1 subunit targets epithelial-to-mesenchymal transition and downregulates Akt pathway in human endometrial and cervical cancer cells

Endometrial and cervical cancer are among the most frequently diagnosed malignancies globally. Nitric oxide receptor-soluble guanylyl cyclase (sGC) is a heterodimeric enzyme composed of two subunits, α1 and β1. Previously we showed that sGCα1 subunit promotes cell survival, proliferation, and migrat...

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Principais autores: Lucas H. Acosta, María Teresa L. Pino, María Victoria Rocca, Jimena P. Cabilla
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-01-01
coleção:Heliyon
Assuntos:
Soluble guanylyl cyclase β1 subunit
Cell death
Cell migration
Endometrial cancer
Cervical cancer
Cell signaling
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405844023111352
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