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In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation

Protein-protein interaction (PPI) networks provide a static map of functional protein interactions, which when combined with algorithms, can prioritize key protein candidates which experimental studies cannot capture. This study, aimed to construct knowledge-based nucleus pulposus (NP)-specific PPI...

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Principais autores: Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Assuntos:
Low back pain
Intervertebral disc degeneration
PPI network
Proteomics
Candidate prioritisation
Prioritisation algorithm
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2001037025001370
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