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The transmembrane domains mediate oligomerization of the human ZIP4 transporter in vivo

Abstract The human (h) ZIP4 is a plasma membrane transporter that functions to increase cytosolic zinc levels. hZIP4 encodes eight transmembrane domains and a large extracellular domain (ECD). This ECD is cleaved from the holo-transporter when cells are zinc-deficient. At the same time, mutations in...

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Váldodahkkit: Yuting Liu, Elizabeth M. Bafaro, Ann E. Cowan, Robert E. Dempski
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2022-12-01
Ráidu:Scientific Reports
Liŋkkat:https://doi.org/10.1038/s41598-022-24782-6
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