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Mechanistic study on nonylphenol-induced liver fibrosis via Pink1/Parkin-mediated mitophagy and lipid droplet degradation in hepatic stellate cells

Background: Liver fibrosis (LF) is a common pathological feature in several chronic liver diseases. Nonylphenol (NP) accumulates in the liver and impairs its function. The mechanism by which NP exposure induces LF remains to be elucidated. Objective: This study aimed to determine whether NP activate...

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Principais autores: Feng Li, Jie Yu, Songhe Wang, Xiao Yang, Hao Yao, Kai Pan, Huawen Yu, Feng Wang, Jie Xu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-10-01
Serier:Ecotoxicology and Environmental Safety
Fag:
Nonylphenol
Liver fibrosis
Mitophagy
Pink1/Parkin
Hepatic stellate cells
Online adgang:http://www.sciencedirect.com/science/article/pii/S0147651325015519
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