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Targeting pleuro-alveolar junctions reverses lung fibrosis in mice

Abstract Lung fibrosis development utilizes alveolar macrophages, with mechanisms that are incompletely understood. Here, we fate map connective tissue during mouse lung fibrosis and observe disassembly and transfer of connective tissue macromolecules from pleuro-alveolar junctions (PAJs) into deep...

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Hauptverfasser: Adrian Fischer, Wei Han, Shaoping Hu, Martin Mück-Häusl, Juliane Wannemacher, Safwen Kadri, Yue Lin, Ruoxuan Dai, Simon Christ, Yiqun Su, Bikram Dasgupta, Aydan Sardogan, Christoph Deisenhofer, Subhasree Dutta, Amal Kadri, Tankut Gökhan Güney, Donovan Correa-Gallegos, Christoph H. Mayr, Rudolf Hatz, Mircea Gabriel Stoleriu, Michael Lindner, Anne Hilgendorff, Heiko Adler, Hans-Günther Machens, Herbert B. Schiller, Stefanie M. Hauck, Yuval Rinkevich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-01-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-024-55596-x
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