Differentiating naturally occurring and disease associated autoantibodies in MPO-ANCA vasculitis through immunogenomic and epitope comparisons

IntroductionANCAs are diagnostic and pathogenic in ANCA-associated vasculitis however ANCAs can persist or reappear in clinical remission. It is a known phenomenon that naturally occurring autoantibodies, including ANCAs, are also detectable in healthy individuals. That autoantibodies do not directl...

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Autori principali:	Dhruti P. Chen, Young-Hyun Moon, Bridget A. Peck, Justin J. Taylor, Ismael Gomez-Martinez, Mark G. Woodcock, Benjamin G. Vincent, Ronald J. Falk, John S. Poulton, Donna O. Bunch
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-06-01
Serie:	Frontiers in Medicine
Soggetti:	ANCA vasculitis autoantibodies epitope MPO PR3 B cells
Accesso online:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1784607/full
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