Drug-likeness prioritised selection identifies anti-Escherichia coli candidates confirmed by molecular docking, dynamics simulations, and antibacterial assays
To address the imbalance between antibacterial potency and developability in cephalosporin discovery against Escherichia coli, we developed a comprehensive screening strategy guided by the principle of maximum drug-likeness. An integrated evaluation framework was established, consisting of 33 indepe...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis Group
2026-12-01
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| coleção: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Assuntos: | |
| Acesso em linha: | https://www.tandfonline.com/doi/10.1080/14756366.2026.2640719 |
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