Abnormal brain iron homeostasis in human and animal prion disorders.
Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrP(Sc)), a beta-sheet rich isoform of a normal cell-surface glycoprotein, the prion protein (PrP(C)). Limited reports suggest imbalance of brain iron homeostasis as a significant associated cause of neu...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science (PLoS)
2009-03-01
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| Edice: | PLoS Pathogens |
| On-line přístup: | http://europepmc.org/articles/PMC2652663?pdf=render |
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