Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

ABSTRACT Myeloid‐derived suppressor cells (MDSCs) play a pivotal role in establishing an immunosuppressive tumor microenvironment (TME), yet the mechanisms underlying their functional activation remain incompletely defined. Here, we identify the Fgl2‐FcγRIIB signaling axis as a critical mediator of...

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Autori principali:	Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2026-06-01
Serie:	Advanced Science
Soggetti:	Fgl2‐FcγRIIB axis immunotherapy MDSCs TEX TME
Accesso online:	https://doi.org/10.1002/advs.202521784
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