A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

Cellular senescence irreversibly arrests cell proliferation in response to oncogenic stimuli. Human cells develop a senescence-associated secretory phenotype (SASP), which increases the secretion of cytokines and other factors that alter the behavior of neighboring cells. We show here that "senescen...

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Bibliographic Details

Main Authors:	Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Ana Krtolica, Christian M Beauséjour, Simona Parrinello, J Graeme Hodgson, Koei Chin, Pierre-Yves Desprez, Judith Campisi
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science (PLoS) 2010-02-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2820538?pdf=render
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