Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

Abstract Background The infectious prion protein (PrPSc or prion) is derived from its cellular form (PrPC) through a conformational transition in animal and human prion diseases. Studies have shown that the interspecies conversion of PrPC to PrPSc is largely swayed by species barriers, which is main...

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Detalhes bibliográficos

Principais autores:	Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Lewis S. Zou, Sedky Hassan, Fei Wang, Hisashi Fujioka, Jan Steyaert, Mentor Mulaj, Witold K. Surewicz, Joaquín Castilla, Alexandre Wohlkonig, Wen-Quan Zou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-10-01
coleção:	Microbial Cell Factories
Assuntos:	Prions Prion protein Prion diseases Quiescin sulfhydryl oxidase (QSOX) Bank vole Thioflavin T (ThT)
Acesso em linha:	http://link.springer.com/article/10.1186/s12934-017-0782-x
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