Insights from aquaporin structures into drug-resistant sleeping sickness

Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentamidine and melarsoprol through mutations in the aquaglyceropori...

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Bibliografiske detaljer

Principais autores:	Modestas Matusevicius, Robin A Corey, Marcos Gragera, Keitaro Yamashita, Teresa Sprenger, Marzuq Ungogo, James N Blaza, Pablo Castro-Hartmann, Dimitri Y Chirgadze, Sundeep Chaitanya Vedithi, Pavel Afanasyev, Roberto Melero, Rangana Warshamanage, Anastasiia Gusach, José-Maria Carazo, Mark Carrington, Tom Blundell, Garib N Murshudov, Phillip J Stansfeld, Mark SP Sansom, Harry P De Koning, Christopher G Tate, Simone Weyand
Format:	Artigo
Sprog:	Inglês
Udgivet:	eLife Sciences Publications Ltd 2026-01-01
Serier:	eLife
Fag:	cryo-EM structure aquaporin
Online adgang:	https://elifesciences.org/articles/107460
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