Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity

Abstract Small molecule inhibitors designed to specifically target oncogenic proteins have demonstrated potent anti-tumour activities due to direct effects on tumour cells survival and/or proliferation. However, the effects of these compounds on normal cells, specifically immune cells and their pote...

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Hauptverfasser:	Dane M. Newman, Courtney L. Andersen, Leonie A. Cluse, Andrea Newbold, Peter Fraser, Benjamin W. C. Legg, Luyao Kevin Xu, Deanna A. Mele, Ricky W. Johnstone
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2026-01-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-025-08354-w
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