Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation

Oligomeric assemblies of neurotoxic amyloid beta (Abeta) peptides generated by proteolytical processing of the amyloid precursor protein (APP) play a key role in the pathogenesis of Alzheimer’s disease (AD). In recent years, a substantial heterogeneity of Abeta peptides with distinct biophysic...

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Detalhes bibliográficos

Principais autores:	Maike Hartlage-Rübsamen, Alexandra Bluhm, Anke Piechotta, Miriam Linnert, Jens-Ulrich Rahfeld, Hans-Ulrich Demuth, Inge Lues, Peer-Hendrik Kuhn, Stefan F. Lichtenthaler, Steffen Roßner, Corinna Höfling
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2018-04-01
coleção:	Molecules
Assuntos:	Alzheimer’s disease animal model human APP expression glutaminyl cyclase pyroglutamate-Abeta
Acesso em linha:	http://www.mdpi.com/1420-3049/23/4/924
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