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Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice

Background & aims: Genome-wide studies have identified three missense variants in the human gene ACVR1C, encoding the TGF-β superfamily receptor ALK7, that correlate with altered waist-to-hip ratio adjusted for body mass index (WHR/BMI), a measure of body fat distribution. Methods: To move from...

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Principais autores: Pawanrat Tangseefa, Hong Jin, Houyu Zhang, Meng Xie, Carlos F. Ibáñez
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2024-03-01
סדרה:Molecular Metabolism
נושאים:
Adipose tissue
Lipolysis
Obesity
Single-nucleotide variant
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2212877824000218
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