Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons

Abstract Background Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting “normal” mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDNA changes, we developed a moderate throughput mt isola...

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Autors principals:	Parnika S. Kadam, Zijian Yang, Youtao Lu, Hua Zhu, Yasemin Atiyas, Nishal Shah, Stephen Fisher, Erik Nordgren, Junhyong Kim, David Issadore, James Eberwine
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-07-01
Col·lecció:	BMC Biology
Matèries:	Single mitochondrion Single-nucleotide variants Neurons Astrocytes Heteroplasmy
Accés en línia:	https://doi.org/10.1186/s12915-024-01953-7
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