Engineering of <i>Escherichia coli</i> Glyceraldehyde-3-Phosphate Dehydrogenase with Dual NAD⁺/NADP⁺ Cofactor Specificity for Improving Amino Acid Production

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the central metabolism of microbial cells. GAPDHs differ in cofactor specificity and use NAD⁺, NADP⁺, or both cofactors, reducing them to NADH and NADPH, respectively. Sufficient NADPH supply is one of the crit...

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Autori principali:	Ekaterina A. Slivinskaya, Natalia S. Plekhanova, Irina B. Altman, Tatiana A. Yampolskaya
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-05-01
Serie:	Microorganisms
Soggetti:	glyceraldehyde-3-phosphate dehydrogenase NAD<sup>+</sup> NADP<sup>+</sup> cofactor specificity <span style="font-variant: small-caps">l-</span>threonine <span style="font-variant: small-caps">l-</span>lysine
Accesso online:	https://www.mdpi.com/2076-2607/10/5/976
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