Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers

Abstract Background The PLCG2-P522R variant, which encodes a mildly hyperactive form of the PLCγ2 enzyme, has been identified as a protective genetic factor against Alzheimer’s disease (AD). Many recently discovered AD-associated microglial risk genes converge on the TREM2-PLCγ2 signaling pathway, e...

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Egile Nagusiak:	Heli Jeskanen, Sami Heikkinen, Inka Kervinen, Jenni Lehtisalo, Tiia Ngandu, Roosa-Maria Willman, Jessica Rosa, Dorit Hoffmann, FinnGen, Ville Leinonen, Annakaisa Haapasalo, Mari Takalo, Henna Martiskainen, Mikko Hiltunen
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-01-01
Saila:	Alzheimer’s Research & Therapy
Gaiak:	Alzheimer’s Disease PLCG2-P522R PLCG2 Ghrelin TREM2 Onset age
Sarrera elektronikoa:	https://doi.org/10.1186/s13195-026-01957-1
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