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Cytotoxicity Enhancement in Osteosarcoma with Multifunctional I-131 Radiotherapeutic Nanoparticles: In Vitro Three-Dimensional Spheroid Model and Release Kinetics Modeling

This novel radiolabeled chitosan nanoparticle, facilitated with curcumin, increased doxorubicin cytotoxicity and radiosensitivity to MG-63 osteosarcoma cells in a three-dimensional model. Delivery of the anti-epidermal growth factor receptor (EGFR) targeted carboxymethyl chitosan nanoparticles, dire...

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Autori principali: Suphalak Khamruang Marshall, Maneerat Taweesap, Boonyisa Saelim, Verachai Pachana, Nadeeya Benlateh, Sireetorn Sangangam, Achiraya Bumrungsin, Haswanee Kholo-asae, Issaree Wongtechanon
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-01-01
Serie:Molecules
Soggetti:
anticancer
chitosan
curcumin
cytotoxicity
doxorubicin
fractionated dose
Accesso online:https://www.mdpi.com/1420-3049/29/3/630
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