Na⁺/H⁺ Exchanger 1 Inhibition Overcomes Venetoclax Resistance in Acute Myeloid Leukemia

Despite advances with novel targeted agents (e.g., BCL-2 or IDH inhibitors) combined with chemotherapy for acute myeloid leukemia (AML), drug resistance persists. We investigated whether blocking Na⁺/H⁺ exchanger 1 (NHE1) could enhance AML cell sensitivity to the BCL-2 inhibito...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shin Young Hyun, Eun Jung Na, Yu Ri Kim, Yoo Hong Min, June-Won Cheong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-11-01
coleção:	Cells
Assuntos:	acute myeloid leukemia Na-H exchanger 1 venetoclax PI3K/Akt pathway resistance
Acesso em linha:	https://www.mdpi.com/2073-4409/14/22/1759
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!