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Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis

Abstract Microbial production of chemicals may suffer from inadequate cofactor provision, a challenge further exacerbated in yeasts due to compartmentalized cofactor metabolism. Here, we perform cofactor engineering through the decompartmentalization of mitochondrial metabolism to improve succinic a...

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Bibliografische Detailangaben
Hauptverfasser: Vinh G. Tran, Shih-I Tan, Hao Xu, Daniel R. Weilandt, Xi Li, Sarang S. Bhagwat, Zhixin Zhu, Jeremy S. Guest, Joshua D. Rabinowitz, Huimin Zhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-08-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-025-62304-w
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