In silico screening of Andrographis paniculata secondary metabolites as anti-diabetes mellitus through PDE9 inhibition

Background and purpose: Andrographis paniculata (AP) has long been used as an anti-diabetic agent, but the mechanism of action and active substance responsible for the anti-diabetic effect, particularly by inhibiting phosphodiesterase-9 (PDE9), which is one of the targets of anti-diabetic medication...

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Principais autores:	Netty Ino Ischak, La Aman Ode, Hamsidar Hasan, Akram La Kilo, Aiyi Asnawi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wolters Kluwer Medknow Publications 2023-01-01
coleção:	Research in Pharmaceutical Sciences
Assuntos:	andrographis paniculate; anti-diabetic; molecular docking; molecular dynamics pde9; secondary metabolites.
Acesso em linha:	http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=1;spage=100;epage=111;aulast=Ischak
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