Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species

Abstract Background High levels of the polyunsaturated fatty acid arachidonic acid (AA) within the ovarian carcinoma (OC) microenvironment correlate with reduced relapse-free survival. Furthermore, OC progression is tied to compromised immunosurveillance, partially attributed to the impairment of na...

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Detalhes bibliográficos

Principais autores:	Mohamad K. Hammoud, Celina Meena, Raimund Dietze, Nathalie Hoffmann, Witold Szymanski, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-11-01
Colecção:	Cell Communication and Signaling
Assuntos:	Arachidonic acid Cytotoxicity receptors Interleukin 2 Natural killer (NK) cells NKG2D Ovarian carcinoma
Acesso em linha:	https://doi.org/10.1186/s12964-024-01940-z
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