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Reverting <i>TP53</i> Mutation in Breast Cancer Cells: Prime Editing Workflow and Technical Considerations

Breast cancer is the leading cause of cancer-related deaths in women. The aggressive breast cancer subtype is commonly linked to the genetic alterations in the <i>TP53</i> tumor suppressor gene, predominantly the missense mutations. Robust experimental models are needed to gain better insights into...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Asmaa Y. Abuhamad, Nurul Nadia Mohamad Zamberi, Ling Sheen, Safaa M. Naes, Siti Nur Hasanah Mohd Yusuf, Asilah Ahmad Tajudin, M. Aiman Mohtar, Amir Syahir Amir Hamzah, Saiful Effendi Syafruddin
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-05-01
Schriftenreihe:Cells
Schlagworte:
prime editing
CRISPR
TP53
missense mutation
tumor suppressor
breast cancer
Online-Zugang:https://www.mdpi.com/2073-4409/11/10/1612
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