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Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation

Cyclosporin A (CyA) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (TGF-β1) and collagen. It is not known whether CyA has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast transdif...

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Principais autores: Lays Martin Sobral, Michele Gassen Kellermann, Edgard Graner, Hercilio Martelli-Junior, Ricardo Della Coletta
Format: Artigo
Sprog:Inglês
Udgivet: Sociedade Brasileira de Pesquisa Odontológica - SBPqO 2010-06-01
Serier:Brazilian Oral Research
Fag:
Gingival overgrowth
Cyclosporine
Fibroblasts
Transforming growth factor beta
Connective tissue growth factor
Online adgang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242010000200010
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