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Recent advances in immunotherapy for gliomas: overcoming barriers and advancing precision strategies

Gliomas, and particularly glioblastoma (GBM), remain among the most lethal primary brain tumors, with outcomes constrained by extensive intra tumor heterogeneity, a profoundly immunosuppressive tumor microenvironment (TME), and the restrictive nature of the blood–brain barrier (BBB). Although immuno...

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Principais autores: Abdullah Jabri, Abdulaziz Mhannayeh, Bader Taftafa, Mohamed Alsharif, Dania Sibai, Raghad Alsharif, Tasnim Abbad, Abdulrahman Elsalti, Zara Ahmed, Jahan Salma, Mohammed Imran Khan, Ahmed Yaqinuddin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Immunology
Assuntos:
glioblastoma
glioma
immunotherapy
tumor microenvironment
immune checkpoint inhibitors
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1690464/full
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