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Therapeutic potential of Ishophloroglucin a from Ishige okamurae in androgenic alopecia: inhibition of 5α-reductase activity and activation of the Wnt/β-catenin signaling pathway in human dermal papilla cells

Abstract Androgenic alopecia (AGA) is a common condition of hair loss, triggered by excessive 5α-dihydrotestosterone (5α-DHT) generated via 5α-reductase activity. This study investigated the anti-alopecia effects of Ishophloroglucin A (IPA), a compound isolated from the brown seaweed Ishige okamurae...

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Principais autores: Wook-Chul Kim, Hyun-Soo Kim, Nalae Kang, Soo-Jin Heo, Seung-Hong Lee
Format: Artigo
Jezik:Inglês
Izdano: SpringerOpen 2026-01-01
Serija:Applied Biological Chemistry
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Online dostop:https://doi.org/10.1186/s13765-025-01067-w
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