Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects

Abstract Background Curcumin and piperine are major bioactive compounds of Curcuma longa and Piper nigrum, widely consumed as spices and flock medicine. The combinational use of these plants is a common practice in Southeast Asia. Synergism between curcumin and piperine has been found in several ani...

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Autori principali:	Pawana Boonrueng, Peththa Wadu Dasuni Wasana, Hasriadi, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-10-01
Serie:	Chinese Medicine
Soggetti:	CNS side effects Curcumin Formalin test Piperine Synergistic interaction Tail-flick test
Accesso online:	https://doi.org/10.1186/s13020-022-00660-1
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