Dual ET/ET blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension
Dysregulated metabolism and rarefaction of the capillary network play a critical role in pulmonary arterial hypertension (PAH) etiology. They are associated with a decrease in perfusion of the lungs, skeletal muscles, and right ventricle (RV). Previous studies suggested that endothelin-1 (ET-1) modu...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley
2017-11-01
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| coleção: | Pulmonary Circulation |
| Acesso em linha: | https://doi.org/10.1177/2045893217741429 |
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