Ultra-Fast Middle-Up Reversed Phase Liquid Chromatography Analysis of Complex Bispecific Antibodies Obtained in Less Than One Minute

This work illustrates the benefits and limitations of using ultra-short reversed phase liquid chromatography (RPLC) columns for the characterization of various complex bispecific antibodies after prolonged thermal stress at the middle-up level of analysis. First, we have demonstrated that alternativ...

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Detalles Bibliográficos

Principais autores:	Amarande Murisier, Valentina D’Atri, Sebastian Pirner, Vincent Larraillet, Szabolcs Fekete, Matthew Lauber, Davy Guillarme
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-10-01
Series:	Pharmaceutics
Assuntos:	ultra-short columns bispecific antibodies reversed-phase liquid chromatography improved selectivity method robustness
Acceso en liña:	https://www.mdpi.com/1999-4923/14/11/2315
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