2,4-<i>Bis</i>{4-[(dialkylaminoalkyl)aminomethyl]phenyl}-7-substituted-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidine Derivatives: Synthesis and Biological Evaluation as Novel Antiprotozoal Agents by Potentially Targeting G-Quadruplex

A series of substituted pyrrolo[2,3-<i>d</i>]pyrimidines was designed, synthesized, and evaluated in vitro against two protozoan parasites: <i>Plasmodium falciparum</i> and <i>Trypanosoma brucei brucei</i>. Pharmacological studies revealed antiprotozoal activity with IC₅₀ values in the su...

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主要な著者:	Jean Guillon, Solène Savrimoutou, Patrice Agnamey, Vittoria Milano, Céline Damiani, Luisa Ronga, Marie Hanot, Sandra Albenque, Tshering Zangmo, Sarah Monic, Noël Pinaud, Lindita Lari, Mathieu Marchivie, Stéphane Moreau, Jean-Louis Mergny, Serge Moukha, Pascale Dozolme, Clotilde Boudot, Bertrand Courtioux, Anita Cohen, Pascal Sonnet
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-06-01
シリーズ:	Scientia Pharmaceutica
主題:	Pyrrolopyrimidine antimalarial activity antitrypanosomal activity G-quadruplex FRET-melting
オンライン･アクセス:	https://www.mdpi.com/2218-0532/94/2/48
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