Serum Bile Acid Profiling and Mixed Model Analysis Reveal Biomarkers Associated with Pruritus Reduction in Maralixibat-Treated Patients with BSEP Deficiency

Progressive familial intrahepatic cholestasis (PFIC) is a debilitating disease manifest by severe cholestasis, intractable pruritus and growth delay that ultimately leads to liver failure or transplantation. Maralixibat (MRX) was recently approved for the treatment of cholestatic pruritus in patient...

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Bibliografiske detaljer

Principais autores:	Xueheng Zhao, Wujuan Zhang, Pamela Vig, Cory Kostrub, Kenneth D. R. Setchell
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2022-10-01
Serier:	Metabolites
Fag:	bile acid metabolism pruritus linear mixed model biomarker maralixibat
Online adgang:	https://www.mdpi.com/2218-1989/12/10/952
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