RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice

Abstract Background Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, leads to progressive and fatal muscle weakness through yet‐to‐be‐fully deciphered molecular perturbations. Emerging evidence implicates RhoA/Rho‐associated protein kinase (ROCK) signalling in DMD pathology, yet i...

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Главные авторы:	Jae‐Sung You, Yongdeok Kim, Soohyun Lee, Rashid Bashir, Jie Chen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2023-08-01
Серии:	Journal of Cachexia, Sarcopenia and Muscle
Предметы:	Mdx Engineered muscle Force Regeneration XPLN Chloroquine
Online-ссылка:	https://doi.org/10.1002/jcsm.13278
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