Network pharmacology-guided discovery of avicularin from Euphorbia humifusa Willd. targeting IL-17 signaling in psoriasis

Despite therapeutic advances, long-term psoriasis management remains challenged by cost, immunogenicity, and administration barriers. Although the anti-inflammatory properties of avicularin (AL) are recognized, its direct targeting of IL-17RA and its therapeutic efficacy in psoriasis remain unreport...

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Bibliographic Details

Main Authors:	Qianqian Zhou, Zhe Wang, Yuanxiang Wang, Jiawei Guan, Linyun He, Jiwen Yang, Yaping Chi, Li Zhao, Bo Zhang, Kewu Zeng, Hua Zhang, Bo Han
Format:	Artigo
Language:	Inglês
Published:	Compuscript Ltd 2026-03-01
Series:	Acta Materia Medica
Subjects:	psoriasis euphorbia humifusa willd network pharmacology rna-seq spr-ms avicularin
Online Access:	https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2025-0058
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