Effect of Apremilast on LPS-induced immunomodulation and inflammation via activation of Nrf2/HO-1 pathways in rat lungs

Lipopolysaccharides (LPS), the lipid component of gram-negative bacterial cell wall, is recognized as the key factor in acute lung inflammation and is found to exhibit severe immunologic reactions. Phosphodiesterase-4 (PDE-4) inhibitor: “apremilast (AP)” is an immune suppressant and anti-inflammator...

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Detalhes bibliográficos

Principais autores:	Naif O. Al-Harbi, Faisal Imam, Mohammad Matar Al-Harbi, Wajhul Qamar, Khaldoon Aljerian, Md. Khalid Anwer, Mohammed Alharbi, Sultan Almudimeegh, Abdullah S. Alhamed, Ali A Alshamrani
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2023-07-01
coleção:	Saudi Pharmaceutical Journal
Assuntos:	Apremilast Lipopolysaccharides Heme-oxygenase Nitric oxide synthase-2 Western blot Polymerase chain reaction
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1319016423001482
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