Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome

Abstract Background Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by the loss of functional ubiquitin protein ligase E3A (UBE3A). In neurons, UBE3A expression is tightly regulated by a mechanism of imprinting which suppresses the expression of the paternal UBE3A allele. Promisi...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Monica Sonzogni, Peipei Zhai, Edwin J. Mientjes, Geeske M. van Woerden, Ype Elgersma
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-09-01
Edice:	Molecular Autism
Témata:	Angelman syndrome UBE3A Mouse model Behavior Critical period ASO therapy
On-line přístup:	http://link.springer.com/article/10.1186/s13229-020-00376-9
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!