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Epigenetic programming of host lipid metabolism associated with resistance to TST/IGRA conversion after exposure to Mycobacterium tuberculosis

ABSTRACT Mycobacterium tuberculosis (Mtb) exposure leads to a range of outcomes including clearance, latent TB infection (LTBI), and pulmonary tuberculosis (TB). Some heavily exposed individuals resist tuberculin skin test (TST) and interferon-gamma (IFNγ) release assay (IGRA) conversion (RSTR), whi...

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Principais autores: Kimberly A. Dill-McFarland, Jason D. Simmons, Glenna J. Peterson, Felicia K. Nguyen, Monica Campo, Penelope Benchek, Catherine M. Stein, Tomas Vaisar, Harriet Mayanja-Kizza, W. Henry Boom, Thomas R. Hawn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2024-09-01
coleção:mSystems
Assuntos:
Mycobacterium tuberculosis
DNA methylation
chromatin remodeling
interferons
monocytes
Acesso em linha:https://journals.asm.org/doi/10.1128/msystems.00628-24
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